Where is Cuenca, Ecuador? Ecuador is in South America bordered to the north and northeast by Columbia and to the south and southeast by Peru. It is the country highlighted in red on the map above. The Republic of Ecuador straddles the equator. It is bordered by Columbia to the north and northeast and Peru to the south and southeast. Ecuador is one of the smallest countries in South America (it is about the size of the state of Nevada). Yet, Ecuador is one of the most geographically varied countries in the world. Look for CUENCA in the south central part of the country. It’s about a 45-minute flight south of Quito, the capital city. Cuenca has a population of about 400,000 people and is nestled high in the Andes Mountains. How's the weather in Cuenca?  Click the Weather Channel Logo below: Who We Are / What We Do  /  Why We're Here / The Latin American Missions Bureau Where in the World is Cuenca, Ecuador?  /  How You Can Participate in this Ministry Photo Images of Mission Trips in Latin America / Home Foundation of Ecuador Medical Mission Opportunities / Home